In its quest to establish a new pharmaceutical model , Aculys is promoting DX ( Digital Transformation ) in clinical trials and medicine . In this collaborative exploratory study to be launched with Four H , Aculys will collect trial participants ’ subjective assessments of their sleep as well as data on their sleep , activities and heart rate acquired from wearable devices to be worn each night during the clinical trial period . The data will be analysed in conjunction with other data to be obtained in the clinical trial to identify sleep-related digital biomarkers .

This exploratory research programme will be characterised by the following three points :

1 . Objective understanding of narcolepsy , OSAS and its characteristics ( sleep condition , daytime sleepiness , etc ).

2 . Analysis using AI and other methods to collate the subjective assessment by patients and objective assessment obtained by the wearable device .

3 . Development of appropriate and reliable digital biomarkers for future clinical trials and clinical settings .

Through the above approach , the following outcomes are expected : objective understanding of patients ' sleep status , analysis of daytime sleepiness patterns , extraction of sleep characteristics and daytime activity data through comparison with people without symptoms and detection of predictive signs of the onset of daytime sleepiness .

Sleep disorders are difficult to identify and largely rely on the memory and self-reporting of patients themselves , causing a range of challenges in diagnoses and appropriate treatment .

This exploratory research will allow a further accurate understanding of each patient ’ s sleep and lifestyle patterns , which had been difficult to measure previously .

Sleep disorders in Japan

The impact of sleep-related disorders on Japanese society is enormous . Research shows that presenteeism ( decreased productivity at work due to health issues ) and absenteeism ( absence or sick leave due to health issues ) are causing an economic loss of about 3 % of Japanese GDP , equivalent to about ¥ 15 trillion . Japanese people also sleep less than people in other countries due to a lack of understanding about the importance of sleep .

Sleep disorders are also factors that interfere with proper sleep and daytime sleepiness . It has been reported that delays in appropriate medical intervention for sleep disorders and complications associated with sleep disorders increase overall costs to society including medical care expenditure . To improve the patient ’ s quality of life , prognosis , productivity and other factors , it is necessary to detect sleep disorders accurately and provide appropriate medical care at an early stage . �

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