I N D U S T R Y I N V E S T I G A T I O N
To be operator-independent , physical separation is required to mechanically isolate platelets and plasma . The use of polymer separator gels has many advantages . These gels also have thixotropic properties that allow them to become fluid when subjected to a centrifugal force of 1500 × g and return to their original consistency when centrifugation is complete .
At the end of the centrifugation , the separating gel returns to its solid consistency and forms a solid barrier that mechanically separates the blood components .
To obtain PRP , the tube must be gently shaken to resuspend the platelets in the plasma . Because it is the polymer gel that separates the blood components based on their density , PRP isolation in these devices is specific and operator-independent and is therefore reliable and reproducible .
The resulting PRP is a standardised PRP plasma with high platelet recovery without specific loss of the densest platelets , low leukocyte levels , with specific depletion of pro-inflammatory white blood cells and virtually no red blood cells .
PRP prepared with RegenLab devices is approximately 1.5 to 1.7 times the baseline value in whole blood . Due to the high quality of the recovered platelets , this particular lowconcentration PRP has proven to be effective in all therapeutic areas in which it has been tested . If desired , the platelet concentration factor can be increased up to three to four times the baseline value , by discarding plasma .
However , the so-called therapeutic platelet concentration of 1 billion per ml ( four to five times higher than baseline values ) has never been demonstrated in comparative clinical studies and may be limited to leukocyte-rich PRP , as a higher platelet concentration may be required to offset the negative effects of pro-inflammatory white blood cells .
Cellular Matrix
Endogenous hyaluronic acid ( HA ), one of the main components of the extracellular matrix , is a polysaccharide . Because PRP and HA target different pathways and have different functions , when used together , they can have a synergistic effect as a therapeutic approach for healing , inflammation or analgesic purposes .
Cellular Matrix is the first and , to date , the only CE-certified medical device that allows the combination of HA and PRP in compliance with medical device and health regulations . HA creates a cell-friendly matrix in which platelets are suspended . Indeed , HA is an implantable medical device and PRP is a biological drug . Therefore , healthcare professionals are not expected to prepare their own PRP-HA mixture by combining any HA with any PRP , as modifications of medical devices or biological drugs are not permitted .
Conclusion
Regenerative medicine encompasses a wide range of techniques aimed at repairing or even replacing damaged or aged tissue .
Of these , autologous platelet-rich plasma is one of the simplest and most effective . This approach is based on the intrinsic capacity of the human body to self-repair and the role of platelets in this process .
PRP is now a key player in the medical world with millions of patients treated each year . �
Sarah Berndt , PhD in Biomedical and Pharmaceutical Sciences – Head of Cell Therapy Research at Regen Lab AG
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