F E A T U R E hidden costs stemming from the expensive , complex instrumentation required for its operation . The process is further impeded by its incapacity to handle multiple samples concurrently . This lack of automation and effective scalability makes this method far from ideal considering the large cell quantities of T cells necessary for modern T cell therapy treatments . MACS ’ s abrasive nature can also deplete collected cells and compromise their functionality . Given that the genetic modification process already stresses cells , commencing with cells strained by MACS may lead to diminished cell genetic engineering and corresponding treatment efficacy .
For all these reasons , microbubbles prove themselves a superior alternative to current cell separation methods . Microbubbles are hollow particles with thin silica , solid shells . Filled with air , their design allows them to precisely target and isolate specific cells in a sample .
Employing T cell negative selection , microbubbles attach to all cells in a sample except T cells . By employing the novelty of negative cell separation , microbubbles are able to scale this process to clinicalscale manufacturing levels . Utilising their buoyancy , microbubbles use gravity alone to rise to the surface , allowing for their easy removal , along with their bound cells . This leaves T cells untouched at the bottom of the vessel , ready for use .
This floatation-based separation method provides an elegant workflow for professionals , completing the entire procedure within a 60-minute timeframe . This efficient process preserves crucial time between sample collection and treatment . Moreover , their increased scalability allows the simultaneous handling of samples , guaranteeing exceptional yield . The gentle nature of microbubble-based cell separation also prioritises a protocol of simplicity to ensure cell health . By minimising shear forces , microbubbles ensure increased T cell quality and viability , ultimately enhancing the efficacy of patient treatments . Microbubble technology therefore outperforms current cell separation methods on the market , providing increased automation in order to optimise both cell purity and yield . This process also increases the effectiveness of cancer cell therapies , as well as making the therapy more affordable for both patients and providers .
The future of cancer therapy
As a society , we are still a long way off from claiming we have beat cancer . However , with advancing treatments such as CAR T cell therapy , cancer patients are given the best chance of survival after diagnosis . Yet , we must still strive to provide the best therapies possible for patients , which means continuing to perfect treatments which are already on the market . We also have a social responsibility to ensure these treatments are made accessible to all patients , regardless of their financial backgrounds .
Microbubble technology is revolutionising the oncology market , leading the way in ensuring that effective medical care is available to all . By accelerating the cell separation process and producing a higher volume and quality of desired cells , as well as decreasing the manufacturing costs for such treatments like CAR T cell therapy , microbubbles are providing us with a glimpse of a future free from medical-financial constraints and full of effective cancer treatments for suffering patients . �
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