R E G I O N A L C H E C K - U P genomic coverage , enabling the detection of large structural variations and DNA methylation , providing a more complete picture of the genome . This multi-omics approach , combining whole genome sequencing ( WGS ), RNA fulllength sequencing , fibre sequencing and methylation analysis , positions PacBio as an essential contributor to the success of this joint effort with PRECISE .

“ I am delighted that PRECISE has selected our Revio system for their extensive , flagship long-read sequencing project in Singapore ,” said Christian Henry , President and Chief Executive Officer of PacBio . “ PRECISE chose PacBio HiFi technology for its capacity to deliver complete and accurate genomes . This project exemplifies Revio ’ s unique ability to provide differentiated solutions for large-scale , multi-thousand-sample , whole genome sequencing projects .

“ Building diverse reference genomes like the pan-Asian genomes in the PacBio-PRECISE project will ensure inclusive , accurate and equitable health research by reflecting the genetic diversity of the global population .

“ Reference genomes are sequences of DNA intended to serve as a representative examples of a species ’ genetic makeup . Yet the current human reference genome is built primarily from samples of individuals with European ancestry . This lack of diversity means that genetic variants that are common in other populations might be underrepresented or missed entirely . As a result , diagnostics , treatments and precision medicine strategies may be less effective or even inaccurate for non-European populations .”

PacBio ’ s joint effort with PRECISE is set to elevate precision medicine in Singapore , leveraging highly-accurate long-read sequencing to drive

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